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Gleevec Linked to Heart Failure

Staff Writer

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Posted by Staff WriterJuly 27, 2006 1:28 PM

Tags: Defective Drugs

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Jamie Sheller at Philadelphia Personal Injury Lawyer brings my attention to the news that Gleevec, a successful treatment for chronic myelogenous leukemia, had been linked to congestive heart failure in rare cases.

Ten CML patients treated with Gleevec at the M.D. Anderson Cancer Center in Houston developed congestive heart failure, although they had normal heart function when they began taking the drug. Studies in mice and in culture showed that the Abl tyrosine kinase protects cardiac cells from damage; when it is inhibited, heart cells die.

Read the full Gleevec story from MedPage today.

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